Lose Weight With Naltrexone-bupropion

Naltrexone-bupropion is an FDA-approved medication prescribed for weight loss. It is a combination of two drugs, naltrexone and bupropion.

Naltrexone is an opioid receptor antagonist and is commonly used to treat opioid addiction and alcohol dependence. Bupropion is an antidepressant that also aids in smoking cessation.

The combination of these two medications in Naltrexone-Bupropion helps target different aspects of weight management, making it an effective option for weight loss.

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What is Semaglutide ?

Naltrexone-bupropion, marketed under the brand name Contrave, is a prescription medication used to aid in weight loss. It is an approved medication by the United States Food and Drug Administration (FDA) to assist with weight loss in individuals with a body mass index (BMI) of 30 or greater, or those with a BMI of 27 or greater with at least one obesity-related condition such as diabetes, high blood pressure, or high cholesterol.

Naltrexone is an opioid antagonist that works to reduce food cravings. Bupropion, on the other hand, is an antidepressant that helps control appetite and increase energy expenditure.

Wegovy medication

How Does the Naltrexone-Bupropion Work?

Naltrexone and bupropion have different mechanisms of action that contribute to weight loss. Naltrexone blocks opioid receptors in the hypothalamus, reducing the pleasurable feelings and cravings associated with food. Bupropion, on the other hand, enhances the activity of certain neurotransmitters in the brain, including dopamine and norepinephrine, which suppress appetite and increase energy expenditure.

Is Naltrexone-Bupropion Safe and Effective for Weight Loss?

Naltrexone-bupropion has been proven in clinical trials to be effective in aiding weight loss. In a 56-week study, individuals who used naltrexone-bupropion along with lifestyle modifications experienced an average weight loss of 8.1 kilograms (about 9% of their initial body weight) compared to those who took a placebo.

The medication benefits both weight loss and maintaining weight loss when taken as part of a comprehensive weight management plan that includes lifestyle modifications and behavioral therapy. However, it is important to note that individual results may vary, and weight loss cannot be guaranteed.

How Much Does Naltrexone-Bupropion Cost?

The cost of naltrexone-bupropion can vary depending on factors such as insurance coverage and whether you choose the brand name medication or generic options. The brand name Contrave can be expensive, with an estimated cost of up to $300 for a 30-day supply. Generic versions of naltrexone-bupropion are more affordable, typically costing around $40 for a 30-day supply.

How is Naltrexone-bupropion Taken?

Naltrexone-bupropion is an oral medication that is taken twice daily, with or without food. The initial dose is typically low and gradually increased over time to reach the maintenance dose.

It is important to follow the designated dosage and not exceed the recommended dosage. Also, one should avoid consuming high-fat meals when taking this medication, as it can reduce its effectiveness.

How is semaglutide administered?

The dose of naltrexone-bupropion is gradually increased by your doctor, starting at one pill per day for the first week and increasing to two pills twice daily from the second week onward.

It is important to not exceed four pills per day and to take the medication at roughly the same time every day.


Side Effects of Naltrexone-bupropion

Like any medication, naltrexone-bupropion can cause side effects in some individuals. Common side effects may include nausea, constipation, headache, dizziness, insomnia, dry mouth, increased heart rate, or elevated blood pressure. However, some side effects subside as the body adapts to the medication, and it is vital to continue use unless advised by a doctor.

Serious side effects are rare but can occur. Seek immediate medical attention if you experience severe allergic reactions, unusual bleeding or bruising, confusion, hallucinations, seizures, or severe headache.

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Alternative medication

Individuals who cannot use naltrexone-bupropion due to contraindications or have not achieved satisfactory weight loss may consider alternative weight-loss medications such as:

GLP-1 medication
GLP-1 medication